Well I did multiple missons on:
Endgame Doc
Endgame Shade
200 MA - twinked
150 Fixer - twinked
115 Enf - medicore gear
The doc and shade mishs ave all been easy peasy.
4 out of 5 MA mishs are easy peasy run through and kill while fro some reason one out of 5 is really hard. Died a few times when suddenly some aliens started nuking for 3-4k every 3 seconds instead of the usual 1-2k. Must be some weird bad luck on the mobs composition. Also the Aliens in those hard missions have roughly twice the HP or from the normal mobs. I quite enjoyed those missions too and adds more kick to them then just rushing through.
The Fixer missions have been quite easy as well but have to be careful not to run into nukers and kill them asap or they can wipe the floor with the fixer in a few secs. Just like on my MA, nanoresist doesn't seem to matter much to the aliens. even with 2500 NR on the MA up I hardly ever counter a nuke. (MA can interrupt though which the fixer can't)
The enf missions also are way to easy in 3 out of 5 mishs where I kill aliens in under 5 seconds or alpha them outright when perks are up. Sometimes I also get wicked aliens though and have high level scouts that hit for 1-2k non-crit damage which got me killed 2 times. Also come with increased HP. On these I have to say that they prolly are a bit too much for this level.
So seems to be some weird scaling or mob composition problems in the mishs. I kind of like it buy maybe it can be adjusted so the "easy" versions get a bit tought while the "hard" versions get a very small damage nerf on the nukes and scouts.