Originally Posted by
sultryvoltron
The biggest difference is the overall effect of the random event.
In League of Legends running the wrong way has a significant impact. You could run into an enemy tower, run towards the enemy team, run towards your own tower, etc. The overall effect of this random event (old Shaco fear) is significant. It can range from absolutely no effect (running in a straight line towards safety) to completely devastating (running in a straight line towards danger). Both of these results are very frustrating for one player or the other.
If we take the above suggestion of randomly mixing up keybinds and direction inputs the overall effect is similarly significant. The effect could similarly range from no effect (changes AS from keybind 1 to keybind 9, player mashes all buttons and you still get hit with AS) to absolutely devastating (AS gets swapped with CH, player CH's you instead of AS). Similarly, both of these results are frustrating for each player.
That is the kind of game-balance that you never want in your game. You never want an ability to have a potentially devastating effect that does not require player effort to execute.