doc with notum shield :SA team with 1 engi 1 enf, 1 doc, 1 sold, 1 crat, 1 advy should do reasonably well.
nanomage doc for genome and ring of pestilence, 1% reflect from advy, 30% from RRFE, 7% from keeper, 20% from guardian 15% from notum shield
I count 75% poison reflect which means getting a capped hit will require a crap tonne of multipliers vs doc. (I calculated about 60k+ base damage after accounting for 1/2 damage after 10k and 1/4 damage after 12k)
4 blockers will eat 2 fling+2 AS, doc will eat at least one stun, but should be ready with FM. Doc I reckon will survive first volley because agents would underestimate his defence. 5000 layer NM coon is worth 20k after adjustment for reflect. if doc makes it through initial volley, all agents will go down because they'll never be able to recover enough perk damage to take down engi.
I know enf seems like a weird choice but its actually not, because enf gives 2600 max health to doc, and paired with other defences you're looking at a defensive juggernaut that's nearly impossible to take down for 10 seconds, and extremely difficult to take down for 40s. The other thing is enf brings an area stun.
Assuming you're fighting in cluse quarters, an AOE stun while the agents are focussing on the doc (also purify btw) will buy a combined total of 2.5s + 4s = 6.5s of AoE stuns which, if launched immediately could provide enough stopgaps in the special spam for the doc to heal though the first volley.
I would lead with:
1 Bio Regrowth on doc from enforcer
2. pop AMS + guardian
3. cast BI
4. NM notum guard + NM coon
5. Initiate with weekend volunteer and you are next (on different targets), Purify, follow up with bring the pain.
Which put doc in good position to eat onslaught
then as soon as the AoE stuns hit, recast BI and refresh max HP.
the doc should make it through first volley and if he does, I think the fight is lost for the agents. engi uses NSD to remove RRFE, soldier spams CH resist on called target, keeper can spam some blow their cover (I'd be spamming this full time except when clarion is up, then go to town with that one).
Basically, the main problems I see here for agents are as follows:
1. if all fling/AS are activated together, then you run the risk at the very beginning of the fight failing the instagank vs highest concentration of blockers+temp reflect.
2. keeper will debuff agents eventually, AOE stuns, fears, clarion call, brawl, will end up putting AS's on different timers
3. agents must target doctor first for kill or they lose, which means you can set up on doctor to eat damage. As soon as fear/stuns are out, AS's will be on totally different timers and doc will be able to tank damage for about 20 seconds - in this time, at least one agent, if not more will go down, and they'll already be fighting to stay in the fight.
4. if they blow too many perks on doc (highly likely) they'll never take down the engie, especially with procced 13% reflect, 1% from advy and 7% from keeper,
5. Soldier is the key to agent takedown with CH resist on called target which will ensure agents go down rapidly regardless of FP
6. advy team heals can significantly prolong the fight if agents are somehow able to dispatch the engi after doc
7. Clutch: if agents are able to take down engi, there's no way they won't be facing a seriously uneven fight, with stuns from crat/keeper/enf/soldier, crat pets chewing away - agents don't have great crit resist so crat pets do decent damage, plus MB procs, NSD will remain for a bit after engi dies but agents might recover some defence late in fight. Even if agents get engi, it's going to be very tough to decide to go on crat with 20k HP OSB'd vs advy, either way, they won't take out another toon, and the fight will be all but finished with keeper+enf+advy+crat alive with 4 blockers each facing 3 agents with no perks up. No matter how you cut it here, agents can't win. The time it takes to get through a proper healer with blockers and 65%-75% reflects will just be too long, engi, again it's too expensive perk wise.
I mean, there's a reason why docs and engies are the first ones called at towers, its because they are and always have been the defence kings, the ones who can turn the tide of a fight because the other side simply spends far too long trying to take them down. The time it would take 6 agents to take down a doc and engi would be a huge risk, yes, they could do it... but it would cost them the fight.